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. 2023 Nov 7;8:63. doi: 10.1038/s41536-023-00337-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Number of identified differentially expressed genes in immortalized mouse hepatocytes with Mfap4 knockdown and immortalized human hepatocytes with MFAP4 knockdown. b Filtered DEG from (a) with logFC >1 or logFC < −1 showed 108 overlapping genes between mouse and human. c Among 108 overlapped genes, 25 genes were upregulated, 83 genes were downregulated. d Heatmap showed overlapping up- and downregulated genes. e Pathway analysis of overlapping DEG highlights the Reelin signaling pathway, IL-5 regulation of apoptosis, and the BDNF signaling pathway. f Validation of upregulated genes indicated by pathway analysis (qPCR). g Proposed mechanism of action upon Mfap4 knockdown. This figure was created by the authors V.I. and N.A.K. with BioRender.com.