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. 2023 Nov 7;6:1127. doi: 10.1038/s42003-023-05511-9

Fig. 1. Ubiquitinylated proteins accumulate in AD brains, and proteasome activity is impaired in human cortical slices exposed to AβOs in culture.

Fig. 1

Immunoreactivities of polyubiquitin (n = 10 control, 11 AD) (a), 20S subunit α1 (n = 9 control, 11 AD) (b) and 19S subunit Rpt6 (n = 5 control, 9 AD) (c) were quantified in AD hippocampi compared to controls; two-tailed unpaired Student’s t test. d–f Chymotrypsin-, trypsin- and caspase-like proteasome activities in human adult cortical slices in culture exposed to vehicle or 0.5 µM AβOs for 24 h (n = 5 independent donors; two-tailed unpaired Student’s t test). g, h Proteasome 20S subunit α1 and 19S subunit Rpt6 immunoreactivities in human cortical slices in culture. GAPDH was used as loading control (n = 4 independent donors; two-tailed unpaired Student’s t test). Data are presented as mean ± SEM.