TABLE 1.

Binding affinities, no. of hydrogen bonds, and participating amino acids of three ligands with nine selected proteins.

Serial No.	Ligand name	Protein name	Binding energy (kcal/Mol)	No. of H‐bonds	Participating amino acids
1	Punicalin	PPAR‐γ	−8.1	3	Arg, Ser
2		GFAT	−9.2	6	Asp, His, Tyr, Gln, Arg, Glu
3		PTP1‐β	−9.3	9	Gly, Gln, Pro, Arg, Trp, Asp
4		RBP‐4	−9.1	5	Gln, Asp, Arg, Gln
5		AQP‐2	−10.1	10	Glu, Arg, Leu, Arg, Ile, His, Gly
6		GCK	−9.5	6	Ser, Gln, Thr, Gly, Lys, Ser
7		α‐Amylase	−11.3	8	His, Thr, Glu, Lys
8		α‐Glucosidase	−9.2	3	Asn, Arg
9		TK‐IR	−8.5	6	His, Leu, Asp, Arg, Gly
10		PPAR‐γ	−8.5	4	Arg, Gln, His
11		GFAT	−10	7	Arg, Tyr, Gln, His, Asp, Glu, Ser, Pro, Met
12		PTP1‐β	−9.9	10	Asp, Gln, Arg, Lys, Asp, Phe, Glu
13	Punicalagin	RBP‐4	−8.9	4	His, Arg, Gln
14		AQP‐2	−10.4	3	Gly, Asp, His
15		GCK	−9.0	5	Ser, Arg, Asn, Asp
16		α‐Amylase	−10.2	9	Asp, Arg, Pro, Gly, Ser
17		α‐Glucosidase	−9.4	4	Asp, Arg, His
18		TK‐IR	−9.0	1	Arg
19	Ellagic acid	PPAR‐γ	−8.1	3	Gln, Asp, Arg
20		GFAT	−8.0	5	Gln, Glu, Asn, Gly, Pro
21		PTP1‐β	−8.0	8	Gly, Ser, Gln, Trp, Asp
22		RBP‐4	−6.8	5	Ser, Lys, Cys, Leu
23		AQP‐2	−8.7	6	His, Val, Arg, Gly
24		GCK	−7.8	3	Lys, Arg
25		α‐Amylase	−8.3	2	His, Pro
26		α‐Glucosidase	−8.3	3	Ser, Pro, Arg
27		TK‐IR	−8.1	2	Asp, Phe