Figure 5: Predictable preference index (PPI) for MGB unit’s sensitive to stimulus depth of modulation:

PPI’s were calculated (see text) for MGB responses to random and predictable trials across all $f_{\text{mods}}$ combined and for specific subsets of $f_{\text{mods}}$ A. For all $f_{\text{mods}}$ combined, MGB units (n = 56) showed significant increases in PPI values (red bar) when switching from ${\text{SAM}}_{\mathrm{\Delta }100\text{\%}}$ to less distinct ${\text{SAM}}_{\mathrm{\Delta }25\text{\%}}$ stimuli (blue bar). The observed increase in PPI was reversed (green bar) with corticothalamic (CT) blockade. B. PPI values for MGB neurons showed significantly increased PPIs to ${\text{SAM}}_{\mathrm{\Delta }25\text{\%}}$ especially at higher $f_{\text{mods}}$ with CT blockade reversing these increases. (Data are presented as the mean ± SEM; repeated-measures ANOVA followed by post hoc Tukey’s correction were used for analyses (Graphpad). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001.