Figure 8. Salience based generation of predication errors in auditory thalamus:

An upcoming sensory signal from inferior colliculus (IC) at the level of medial geniculate body (MGB) could interact with a top-down prediction from cortex, and generate prediction error component. The upcoming sensory signals (spikes) generated in response to distinct stimuli, are matched by the top-down predictions and hence little to less generation of prediction error component upon repetition of the distinct stimuli (A). The spike signals to weakly modulated stimuli fail to match the predictions, hence generation of prediction error increases upon repetition until the occurrence of a correct prediction based on the new internal representation formed by feedback from previous prediction error signals. This phenomenon is observed as an increase in response to each repetition (repetition enhancement) (B). CT blockade with weakly modulated stimuli, leads to blockade of delivery of predictions to MGB, and possibly erroneous prediction error signals and adaptive spike responses (C).