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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257

Fig. 1. Taurine deficiency is a driver of aging in evolutionarily divergent species.

Fig. 1.

(A-C) Serum taurine levels in female mice at different ages (A), in young (5-year-old) and old (15-year-old) female monkeys (B), and in humans at different ages (C). (D-E) Lifespan assay of middle-aged (14-month-old) wild-type (WT) female (D) and male (E) C57Bl/6J mice orally fed taurine (T, 1000 mg/kg BW/day) at 10:00 h till the end of life. (F) Lifespan assay of wild-type nematodes that were fed diet supplemented with different concentrations of taurine (0, 10, 50, 100, 150, and 300 μM). (G) Replicative lifespan (RLS) assay in yeast cultured on YPD plates with different concentrations of taurine (0, 300, 1000, and 100,000 μM). (H) Phylogenetic analysis of taurine biosynthesis enzymes in eukaryotes. Statistical analysis: The OASIS software (http://sbi.postech.ac.kr/oasis) was used for calculating p-values using a log rank test (the Mantel–Cox method) in mice and worm experiments. Wilcoxon rank-sum test was used by for calculating p-values in yeast RLS assays. N is represented within panels. All values are mean ± SEM. p ≤ 0.0001****, p ≤ 0.001***, p ≤ 0.01**, and p ≤ 0.05* are versus WT or control.