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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257

Fig. 2. Taurine supplementation increases healthspan in aged mice.

Fig. 2.

(A-K) Changes in body weight (A), Fat % (B), bone structure, and strength parameters in spine and femur (C-D), neuromuscular and muscle strength (E-F, rotarod, wire hang, and grip-strength tests), anxiety (G, tail suspension and dark-light tests), memory (H, Y maze test), pancreas function (I, glucose and insulin tolerance tests), gastrointestinal (GI) transit (J, oral carmine dye test), and immunophenotyping (K, immune cell parameters in blood) in 24-month-old wild-type C57Bl/6J female mice orally fed, once daily with taurine (0, 500 or 1000 mg/kg BW/day) from middle-age (14 months). Statistical analysis was performed using Graph Pad Prism 7. Data were considered statistically significant at p ≤ 0.05 using the Student’s t-test, one-way or two-way ANOVA. n is represented within panels. All values are mean ± SEM. ns, not significant. p ≤ 0.001***, p ≤ 0.01**, and p ≤ 0.05* are versus WT or control.