Table 3.
Details of the clinical, histological, immunohistochemical, and outcomes of concurrent gastric cancer and gastrointestinal stromal tumor summarized in this study and literature review
|
Ref.
|
Sex
|
Age in yr
|
GC
|
GIST
|
Outcome
|
||||||||
|
Location
|
Size (cm)
|
TNM status
|
Lauren
|
Differentiation
|
Location
|
Size (cm)
|
Risk
|
CD117
|
CD34
|
||||
| Maiorana et al[6], 2000 | F | 81 | Cardias | 4.0 | T2bN0M0, IB | Intestinal | NA | Fundus | 5.0 | L | NA | 21 m, DOD | |
| F | 79 | Antrum | 2.0 | T1bN0M0, IA | Diffuse | Pylorus | 6.0 | H | + | 54 m, PFS | |||
| M | 75 | Antrum | 4.0 | T2bN1M0, IIA | Intestinal | Antrum | 5.0 | L | 12 m, PFS | ||||
| F | 79 | Pylorus | 1.2 | T2aN1M0, IIA | Intestinal | Cardias | 5.0 | L | + | 28 m, PFS | |||
| M | 79 | Antrum | 2.0 | T2aN0M0, IB | Intestinal | Cardias | 0.6 | V-L | + | 75 m, PFS | |||
| Bircan et al[7], 2004 | 71 | Antrum | 5.7 | T3NxM0 | Intestinal | P | Cardias | 0.5 | V-L | + | + | NA | 71 |
| 77 | Cardias | 7.5 | T2N1M0, IIA | NA | M | Cardias | 0.6 | V-L | + | + | NA | 77 | |
| Villias et al[8], 2008 | M | 78 | Antrum | NA | T1N0M0, IA | Intestinal | M | Antrum | 0.9 | V-L | + | + | NA |
| Lin et al[9], 2006 | F | 70 | Cardias | 1.7 | T1N0M0, IA | NA | P, SRCC | Fundus | 1.1 | V-L | + | + | 14 m, PFS |
| Liu et al[10], 2018 | M | 72 | Antrum | 4.0 | T2N1M0, IIA | NA | M | Fundus | 2.0 | V-L | + | + | 18 m, PFS |
| Wronski et al[11], 2006 | F | 64 | Antrum | 5.0 | T4N0M0, IIB | Diffuse | NA | Cardias | 2.0 | L | + | + | NA |
| M | 66 | Cardias | 1.0 | T1N0M0, IA | Intestinal | NA | Cardias | 1.0 | V-L | + | + | NA | |
| Theodosopoulos et al[63], 2011 | M | 80 | Antrum | 6.5 | T1N0M0, IA | Intestinal | W | Body | 3.0 | IN | + | NA | 12 m, PFS |
| Rauf et al[46], 2006 | F | 70 | Antrum, body | 10.0. | T4N1M0, IIIA | Diffuse | P, SRCC | Body | 2.0 | L | + | + | 18 m, DOD |
| Namikawa et al[14], 2021 | M | 74 | Body | 2.0 | T2N0M0, IB | NA | M | Body | 2.2 | L | NA | NA | 1 m, PFS |
| Shimodate et al[15], 2014 | M | 79 | Body | 3.0 | T1bN0M0, IA | NA | NA | Body | 1.3 | V-L | + | + | NA |
| Khoshnevis et al[16], 2013 | F | 64 | Pylorus | 6.0 | T4N0M0, IIIA | Diffuse | P, SRCC | Fundus, body | 1.0 | H | + | NA | 4 m, PFS |
| Namikawa et al[17], 2016 | M | 58 | Body | 9.0 | T2N1M0, IIA | Diffuse | SRCC | Body | 21.0 | H | NA | NA | 4 m, PFS |
| Kaffes et al[18], 2002 | M | 78 | Antrum | NA | T1N0M0, IA | Diffuse | P | Body | 1.5 | ND | NA | + | 20 m, PFS |
| Uchiyama et al[19], 2007 | M | 74 | Antrum | 1.5 | T1aN0M0, IA | Intestinal | M-P | Body | 0.8 | L | + | + | NA |
| Salemis et al[20], 2008 | F | 78 | Antrum | 6.5 | T4N2M0, IIIA | Diffuse | P | Body | 1.0 | L | + | + | 14 m, DOD |
| Narasimhamurthy et al[21], 2010 | M | 65 | Cardias | 4.0 | T4NxM0 | Diffuse | P | Antrum | 2.5 | L | + | NA | NA |
| Ferreira et al[22], 2010 | M | 52 | NA | 10.2 | T3N1M0, IIB | NA | NA | NA | 1.1 | V-L | + | + | NA |
| F | 65 | NA | 4.8 | T3N1M0, IIB | NA | NA | NA | 0.7 | V-L | + | + | ||
| Gonçalves et al[23], 2010 | M | 74 | NA | NA | NA | NA | NA | NA | 1.2 | V-L | NA | NA | 5 m, DOD |
| M | 67 | NA | NA | NA | NA | NA | NA | 0.3 | V-L | NA | NA | 2 m, DOD | |
| Jeong et al[24], 2011 | M | 74 | Antrum | 3.3 | T1aN0M0, IA | Intestinal | M | Body | 2.0 | V-L | + | + | NA |
| Cai et al[25], 2013 | M | 47 | Cardias | 8.0 | T3N1M0, IIB | NA | P | Cardias | 2.0 | V-L | + | + | NA |
| M | 80 | Antrum | 2.0 | T1N0M0, IA | P | Cardias | 1.5 | V-L | + | + | |||
| M | 60 | Antrum | 8.0 | T3N0M0, IIA | Antrum | 0.6 | V-L | + | + | ||||
| F | 67 | Antrum | 4.0 | T3N1M0, IIB | Body | 0.8 | V-L | + | + | ||||
| M | 78 | Pylorus | 6.0 | T4N2M0, IIIA | Body | 2.5 | L | + | + | ||||
| M | 78 | Body | 10.0 | T3N1M0, IIB | Body | 1.4 | L | + | + | ||||
| F | 59 | Body | 4.0 | T2N1M0, IIA | P | Body | 0.8 | L | + | + | |||
| M | 80 | Antrum | 6.0 | T2N0M0, IB | P | Body | 5.0 | L | + | + | |||
| Liszka et al[26], 2007 | M | 53 | NA | NA | NA | NA | NA | NA | NA | V-L | + | NA | NA |
| M | 63 | NA | NA | NA | NA | NA | NA | NA | L | + | NA | ||
| Yamamoto et al[27], 2012 | M | 67 | Body | 3.0 | T4N0M0, IIB | Diffuse | P | Body | 3.0 | L | + | + | NA |
| Gülpınar et al[28], 2014 | M | 75 | Antrum | NA | T1N1M0, IB | NA | M | Antrum | 1.0 | NA | NA | NA | |
| Trihia et al[29], 2019 | M | 79 | Cardias | 8.5 | NA | Intestinal | M-P | Body | 0.9 | L | + | + | Days, DOD |
| Yan et al[30], 2013 | M | 53 | U | NA | T4N0M0, IIIA | NA | P | NA | 0.4 | V-L | NA | NA | |
| M | 51 | U | NA | T4N3M0, IIIB | M-P | 0.8 | V-L | + | |||||
| M | 62 | U | NA | T4N2M0, IIIA | P | 0.8 | V-L | NA | |||||
| F | 73 | L | NA | T4N3M0, IIIB | P, SRCC | 0.2 | V-L | NA | |||||
| M | 68 | M | NA | T1N0M0, IA | M | 0.8 | V-L | NA | |||||
| F | 46 | L | NA | T1bN0M0, IA | P, SRCCM | 2.5 | L | + | |||||
| M | 78 | U | NA | T4N1M0, IIIA | M | 1.5 | V-L | + | |||||
| M | 66 | U | NA | T4N3M0, IIIB | M-P | 1.5 | V-L | + | |||||
| M | 85 | U, M | NA | T4N2M0, IIIA | P | 1.0 | V-L | + | |||||
| M | 68 | L | NA | T4N0M0, IIB | M | 0.8 | V-L | + | |||||
| M | 69 | U | NA | T4N0M0, IIB | P, SRCC | 2.0 | V-L | + | |||||
| M | 77 | U | NA | T2N1M0, IIA | M | 0.2 | V-L | + | |||||
| M | 71 | L | NA | T4N3M0, IIIB | M-P | 0.6 | V-L | + | |||||
| F | 77 | L | NA | T4N3M0, IIIB | M-P | 0.5 | V-L | + | |||||
| F | 70 | L | NA | T1bN0M0, IA | 0.6 | V-L | + | ||||||
| Vogel et al[31], 2011 | M | 79 | Body | 6.0 | T1N0M0, IA | Diffuse | P, SRCC | Body | 0.8 | V-L | + | NA | 12 m, PFS |
| 1Ozgun et al[32], 2009 | M | 78 | Body | NA | NA | NA | NA | Antrum | 10.0 | H | + | + | |
| Hsiao et al[33], 2009 | M | 75 | Cardias | 1.0 | T1N0M0, IA | NA | W | Cardias | 3.3 | L | + | + | 6 m, DOD |
| Kountourakis et al[34], 2008 | F | 72 | NA | NA | NA | Diffuse | NA | NA | 1.8 | V-L | + | + | 6 m, PFS |
| Lee et al[35], 2007 | M | 82 | Body | 9.5 | T4NxM1, IV | NA | NA | Body | 1.5 | L | + | + | NA |
| Chen et al[36], 2001 | M | 72 | Pylorus | 1.5 | NA | NA | NA | Body | 2.5 | V-L | + | + | NA |
| 1Katsoulis et al[37], 2007 | F | 78 | Cardias | NA | T4N3aM0, IIIB | Diffuse | P | Antrum | 0.9 | V-L | + | NA | NA |
| 1Liu et al[38], 2002 | M | 70 | Cardia, fundus | 8.5 | T4N0M1, IV | Intestinal | NA | Cardia | NA | V-L | + | + | 3 m, DOD |
| 1Toyoda et al[39], 2009 | F | 83 | Body | 9.0 | T4NxM0 | Intestinal | P | Body | 4.5 | H | + | + | 6 m, DOD |
| 1Matsuno et al[40], 2021 | M | 68 | Body | 5.0 | T3N0M0, IIA | NA | M | Body | 0.5 | V-L | + | NA | 2.5 yr, PFS |
| 1Kleist et al[41], 2010 | F | 86 | Body | 6.0 | NA | Intestinal | SRCC | Body | 6.0 | IN | + | + | 11 m, PFS |
| M | 78 | Body | 6.0 | NA | NA | SRCC | Body | 5.5 | IN | + | + | 4 m, DOD | |
| 1Trabelsi et al[42], 2008 | M | 54 | NA | NA | NA | Diffuse | NA | NA | 1.0 | V-L | NA | NA | NA |
| 1Zámecník et al[64], 2005 | F | 93 | Fundus | NA | LGIN, 0 | NA | NA | Fundus | 4.5 | L | + | + | NA |
| 1Idema et al[43], 2008 | M | 71 | Body | 5.0 | T4N2M0, III A | Intestinal | SRCC | Body | 0.6 | V-L | + | + | 30 m, DOD |
| Alkaaki et al[65], 2018 | M | 55 | Cardia | 1.7 | T1aNxM0 | NA | NA | Antrum | 10 | H | - | + | NA |
| 1Bi et al[66], 2009 | F | 73 | Fundus, body | 4.0 | T4N2M0, III A | Intestinal | W | Fundus | 4 | L | + | + | NA |
| 1Firat et al[44], 2010 | M | 63 | Cardia | 9.0 | T4N3bM0, IIIB | Intestinal | NA | Cardia | 0.4 | V-L | + | + | 13 m, DOD |
| M | 60 | Body | 4.0 | T1N0M0, IA | Intestinal | Body | 0.5 | V-L | + | + | 12 m, PFS | ||
| Telugu et al[67], 2016 | M | 63 | Cardia | 4.0 | T3N1M0, IIB | NA | M | Fundus | 1.0 | V-L | - | + | 7 m, PFS |
| Lin et al[45], 2014 | M (32), F (10) | > 60 (30), ≤ 60 (12) | NA | NA | IA (14), IB (8), IIA (5), IIB (1), IIIA (7), IIIB (4), III C (3) | NA | W (6), M (21), P (10), SRCC (5) | U (14), M (20), L (8) | ≤ 2 (35), 2-5 (7) | V-L (35), L (4), IN (2), H (1) | + (28) | + (25) | 3-yr (62.6), 5-yr (57.8%) |
| Liu et al[52], 2009 | M (19), F (3) | 64.5, (Med) | NA | NA | NA | NA | NA | Cardias (1), fundus (7), body (13), antrum (1) | 0.8 (Med) | < L | 5-yr (31.8%) | ||
| Present study | M (17), F (2) | 62 (Med) | U (5), M (6), L (7), W (1) | 3.5 (Med) | 0 (1), IA (3), IB (3), IIA (3), IIB (3), III A (4), IIIC (2) | Diffuse (6), intestinal (5), mixed (3) | M-P (7), M (5), P (5), W (1) | Body (8), fundus (3), antrum (2), Cardia (2) | 1.4 (Med) | L (10), V-L (7), H (2) | + (19) | + (18), - (1) | 3-yr (73.9%), 5-yr (59.2%) |
| All | M (122), F (35) | 70 (Med) | U (26), M (23), L (35) | 4 (Med) | 0 (2), IA (33), IB (16), IIA (17), IIB (13), IIIA (21), IIIB (11), IIIC (5), IV (2) | Diffuse (19), intestinal (23), mixed (3) | M-P (13), M (38), P (45), W (10) | U (43), M (66), L (20) | 1.2 (Med) | V-L (84), L (35), IN (5), H (9) | - (2) | - (1) | 3-yr (54.5%), 5-yr (46.7%) |
1
Collision tumor.
GC: Gastric cancer; GIST: Gastrointestinal stromal tumor; M: Male; F: Female; Med: Median; DOD: Dead of disease; U: Upper one-third of the stomach; M: Middle one-third of the stomach; L: Lower one-third of the stomach; LGIN: Low-grade intraepithelial neoplasia; M-P: Moderately to poorly differentiated; M: Moderately differentiated; P: Poorly differentiated; W: Well differentiated; SRCC: Signet-ring cell carcinoma; V-L: Very low; L: Low; IN: Intermediate; H: High; SRCC: Signet-ring cell carcinoma; NA: Not assessed; PFS: Progression-free survival; pTNM: Pathological tumor-node-metastasis.