Table 1. Search terms for the detailed literature search and the obtained results.

Database	Date of search	Search term	Total number of studies
PubMed	08-06-2023	“(Alzheimer Dementia) OR (Alzheimer Dementias)) OR (Dementia, Alzheimer)) OR (Alzheimer's Disease)) OR (Senile Dementia)) OR (Dementia, Alzheimer Type)) OR (Alzheimer-Type Dementia (ATD))) OR (Alzheimer Type Dementia (ATD))) OR (Dementia, Alzheimer-Type (ATD))) OR (Alzheimer Type Senile Dementia)) OR (Primary Senile Degenerative Dementia)) OR (Alzheimer Sclerosis)) OR (Alzheimer Syndrome)) OR (Alzheimer's Diseases)) OR (Alzheimer Diseases)) OR (Alzheimers Diseases)) OR (Senile Dementia, Alzheimer Type)) OR (Acute Confusional Senile Dementia)) OR (Dementia, Presenile)) OR (Alzheimer Disease, Late Onset)) OR (Alzheimer's Disease, Focal Onset)) OR (Familial Alzheimer Disease (FAD))) OR (Familial Alzheimer Diseases (FAD))) OR (Alzheimer Disease, Early Onset)) OR (Early Onset Alzheimer Disease)) OR (Presenile Alzheimer Dementia)”	213,139
PubMed	08-06-2023	“(Blue, Methylene) OR (Methylthioninium Chloride)) OR (Methylthionine Chloride)) OR (Swiss Blue)) OR (Basic Blue 9)) OR (Methylene Blue N)) OR (Chromosmon)) OR (Urolene Blue)”	25,843
PubMed	08-06-2023	“(Blue, Methylene) OR (Methylthioninium Chloride)) OR (Methylthionine Chloride)) OR (Swiss Blue)) OR (Basic Blue 9)) OR (Methylene Blue N)) OR (Chromosmon)) OR (Urolene Blue)) AND (Alzheimer Dementia) OR (Alzheimer Dementias)) OR (Dementia, Alzheimer)) OR (Alzheimer's Disease)) OR (Senile Dementia)) OR (Dementia, Alzheimer Type)) OR (Alzheimer-Type Dementia (ATD))) OR (Alzheimer Type Dementia (ATD))) OR (Dementia, Alzheimer-Type (ATD))) OR (Alzheimer Type Senile Dementia)) OR (Primary Senile Degenerative Dementia)) OR (Alzheimer Sclerosis)) OR (Alzheimer Syndrome)) OR (Alzheimer's Diseases)) OR (Alzheimer Diseases)) OR (Alzheimers Diseases)) OR (Senile Dementia, Alzheimer Type)) OR (Acute Confusional Senile Dementia)) OR (Dementia, Presenile)) OR (Alzheimer Disease, Late Onset)) OR (Alzheimer's Disease, Focal Onset)) OR (Familial Alzheimer Disease (FAD))) OR (Familial Alzheimer Diseases (FAD))) OR (Alzheimer Disease, Early Onset)) OR (Early Onset Alzheimer Disease)) OR (Presenile Alzheimer Dementia)”	158
Scopus	08-06-2023	"Methylene Blue" OR "Methylthioninium Chloride" OR "MB" OR "Methylene Azure" AND "Alzheimer's Disease" OR "Alzheimer Disease" OR "AD"	1,126