Table 1.
Patient baseline characteristics
| Primary TORS (n = 116) | Primary RT (n = 51) | p value | |
|---|---|---|---|
| Age, median (IQR) | 59.0 (53.0–64.5) | 58.0 (53.0–65.0) | 0.460 |
| Smoking history | 0.140 | ||
| Never smoker | 40 (34.5) | 18 (35.3) | |
| Former smoker | 58 (50.0) | 19 (37.3) | |
| Current smoker | 18 (15.5) | 14 (27.5) | |
| Smoking history ≥10 pack-years | 60 (51.8) | 26 (51.0) | 0.680 |
| Alcohol use | 65 (56.0) | 20 (39.2) | 0.045 |
| Primary site | 0.009 | ||
| Tonsil | 78 (67.2) | 22 (43.1) | |
| Base of tongue | 37 (31.9) | 29 (56.9) | |
| Other | 1 (0.9) | 0 (0) | |
| Clinical T stage (AJCC 8th Ed.) | 0.0001 | ||
| T0 | 3 (2.6) | 0 (0) | |
| T1 | 60 (51.7) | 10 (19.6) | |
| T2 | 53 (45.7) | 41 (80.4) | |
| Clinical N stage (AJCC 8th Ed.) | <0.0001 | ||
| N0 | 25 (21.6) | 1 (2.0) | |
| N1 | 84 (72.4) | 33 (64.7) | |
| N2 | 7 (6.0) | 17 (33.3) | |
| Pathological T stage (AJCC 8th Ed.) | ‐ | ‐ | |
| T1 | 55 (47) | ||
| T2 | 57 (49) | ||
| T3 | 4 (3) | ||
| Pathological N stage (AJCC 8th Ed.) | ‐ | ‐ | |
| N0 | 16 (14) | ||
| N1 | 83 (72) | ||
| N2 | 16 (14) | ||
| Nx | 1 (1) | ||
| LN >4 cm | 24 (20.7) | 10 (19.6) | 0.730 |
| ECOG | 0.310 | ||
| 0 | 56 (48.3) | 21 (41.2) | |
| 1 | 57 (49.1) | 30 (58.8) | |
| 2 | 3 (2.6) | 0 (0) | |
| Charlson Comorbidity Index, median (IQR) | 1 (0–2) | 2 (1–3) | 0.037 |
| Diabetes | 16 (13.8) | 4 (7.8) | 0.280 |
| Baseline workup | |||
| CT neck/chest | 112 (96.6) | 50 (98.0) | 0.600 |
| PET/CT | 91 (78.5) | 49 (96.1) | 0.004 |
Data presented as number (%) unless otherwise specified. All tumor stage details are by the AJCC 8th Ed. RT, radiotherapy; TORS, transoral robotic surgery.