FIGURE 6.

Mitochondrial transplantation (MITO) increases intracellular signaling pathway genes in a donation after cardiac death kidney model. Pathway analysis for transcript modulations after 24 hour perfusion between treatment (MITO T24) versus control (CTRL T24) (fold change >1.5 or < −1.5; P <0.05) was performed using Ingenuity Pathway Analysis software (IPA, Qiagen). Increased expression of signaling pathway genes was observed, including G proteins/adenylyl cyclases/cAMP signaling mediators, MAPK/ERK and PI3K/AKT genes, and increased levels of ELK1 and CREB transcription factors. Results show the interaction of common activated signaling pathway genes after MITO. Upregulated genes in dataset are represented in blue.