Table.
Concentrations of the TKIs Used in this Study
| Selleckchem | Heldin Literature Review22 | Titration Studies From This Study | |
|---|---|---|---|
| Axitinib | 1.6 nM | 1.6 nM | 2 nM |
| Dasatinib | Not given* | 28 nM | 8 nM |
| Imatinib | 100 nM | 380 nM | 86 nM |
| Sunitinib | 2 nM | 10 nM | 5.6 nM |
*
The manufacturer does not give dasatinib IC50 for PDGFRβ. Still, the manufacturer states that dasatinib targets Abl, Src, and c-Kit with IC50 of <1 nM, 0.8 nM, and 79 nM in cell-free assays, respectively. In this study, we used 100 nM dasatinib as previously described.5