Table 1.

FDA-approved antiretroviral drugs for HIV.

Drug Class	Mode of action	Drugs
Nucleoside Reverse Transcriptase Inhibitors	Reverse transcriptase blocker	Abacavir*
		Emtricitabine*
		Lamivudine*
		Tenofovir disoproxil fumarate* Tenofovir alafenamide*
		Zidovudine*
Non-Nucleoside Reverse Transcriptase Inhibitors	Reverse transcriptase blocker	Doravirine
		Efavirenz*
		Etravirine
		Nevirapine*
		Rilpivirine
Protease Inhibitors	HIV protease blocker	Atazanavir*
		Darunavir*
		Fosamprenavir
		Ritonavir*
		Lopinavir*
		Tipranavir
HIV capsid inhibitor	Interferes with capsid assembly	Lenacapavir
Fusion Inhibitor	Binds CD4 receptors, blocking fusion	Enfuvirtide
CCR5 Antagonist	Binds CCR5, preventing viral entry	Maraviroc
Integrase Strand Transfer Inhibitors	Binds the integrase-viral DNA complex	Cabotegravir
		Dolutegravir*
		Raltegravir*
		Bictegravir
Attachment Inhibitor	Binds gp120, preventing viral entry	Fostemsavir
Post-Attachment Inhibitor	Binds gp120-CD4 complex, preventing coreceptor engagement	Ibalizumab
Pharmacokinetic Enhancer	Inhibits key liver enzymes that decrease bioavailability of protease inhibitors	Cobicistat
Combination	Multiple targets	Bictegravir Emtricitabine Tenofovir alafenamide

^*WHO recommended first and second line regimen drugs.