Table 1.
Characteristics of SLC34A3 Ser192Leu heterozygotes and controls without SLC34A3 variants
| Characteristic | SLC34A3 Ser192Leu heterozygotes (n=218) | Controls (n=168,882) | aORa (95% CI) |
|---|---|---|---|
| Follow-up time, yr (SD) | 14.72 (5.49) | 13.85 (6.00) | |
| Age, yr (SD) | 58.64 (18.56) | 57.36 (18.91) | |
| Female, % | 136 (62) | 101,952 (61) | |
| European ancestry, % | 213 (99) | 155,440 (94) | |
| eGFR available, % | 190 (87) | 148,628 (88) | |
| eGFR, ml/min per 1.73 m2 | 74.23 (23.55) | 80.91 (26.70) | |
| CKD eGFR stage | |||
| ≥90 ml/min per 1.73 m2 | 52 (27) | 52,698 (35) | |
| 60–89 ml/min per 1.73 m2 | 86 (45) | 65,831 (44) | |
| 30–59 ml/min per 1.73 m2 | 46 (24) | 24,897 (17) | |
| 15–29 ml/min per 1.73 m2 | 3 (2) | 2396 (2) | |
| <15 ml/min per 1.73 m2 | 3 (2) | 2962 (2) | |
| Serum phosphate available, % | 96 (44) | 39,636 (23) | |
| Minimum serum phosphate, mg/dl | 2.76 (0.73) | 3.08 (0.69) | |
| Median serum phosphate, mg/dl | 3.17 (0.66) | 3.43 (0.61) | |
| Nephrolithiasis ICD code, % | 28 (13) | 9767 (6) | 2.38 (1.59 to 3.56); P < 0.001 |
| Minimum phosphate <2.5 mg/dl, % | 31/96 (32) | 6226/39,636 (16) | 2.67 (1.74 to 4.11); P < 0.001 |
| Median phosphate <3.0 mg/dl, % | 27/96 (28) | 5768/39,636 (15) | 2.42 (1.52 to 3.86); P < 0.001 |
| Both minimum phosphate <2.5 and median phosphate <3.0 mg/dl, % | 21/96 (22) | 3125/39,636 (8) | 3.41 (2.05 to 5.68); P < 0.001 |
| eGFR <60, ml/min per 1.73 m2 | 52/190 (27) | 30,255/148,784 (20) | 1.45 (1.01 to 2.07); P = 0.04 |
| Kidney/Liver cysts, % | 11/218 (5) | 5084/168,882 (3) | 1.68 (0.92 to 3.08); P = 0.09 |
ICD 9/10 codes used were as follows: nephrolithiasis (N20, 592.0, 592.1, 592.9, 594.0, 594.1, 594.2, 594.8, 594.9, and 274.11) and kidney/liver cysts (Q61.2, Q61.3, 753.13, 753.12, 753.10, Q61.5, Q61.8, Q61.9, Q61.00, Q61.01, Q61.02, 753.11, 753.19, Q44.6, 573.8, and 751.62). aOR, adjusted odds ratio; CI, confidence interval; SLC34A3, solute carrier family 34, member 3; ICD, International Classification of Diseases.
a
Analyses are adjusted for age, sex, and genetic ancestry and clustered by family network.