Fig. 1. T₈sen^high status is not associated with systemic inflammation, plasmatic oxidative stress, or type I IFN signature.

(A) Dosage of inflammatory proteins, IFNs, and IFN-associated proteins was assessed on 79 thawed plasma from patients with aNSCLC. Dosage of oxidative stress–associated molecules MPO and elastase was performed on 94 thawed plasma from patients with aNSCLC. Whole-blood immunophenotyping of T₈sen cells was assessed on the samples. Concentrations of proteins (in pg/ml except for IFN-α in fg/ml) were log₂-normalized and analyzed according to T₈sen status. (B) Relative expression of ISG and type I IFN score were assessed by RT-qPCR on thawed PBMC from 43 patients with aNSCLC and compared between T₈sen^high and T₈sen^low patients. Differences between groups are analyzed by Mann-Whitney test.