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. 2023 Nov 8;9(45):eadh0708. doi: 10.1126/sciadv.adh0708

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Fig. 2. — Pan-virus serological profile (VirScan) was assessed in the serum of 176 patients with aNSCLC. (A and B) Scatter plots representing the mean enrichment of antipeptide antibodies in T₈sen^low (A) and T₈sen^high (B) patients. (C) Volcano plot representing the mean percent of T₈sen in peptide-positive patients divided by that of peptide-negative patient (fold change). Horizontal dotted line defines a P value of 0.01 (in the context of multiple testing), and the vertical dotted line represents a meaningful 40% fold change of percentage of T₈sen cells between peptide-positive and peptide-negative patients (i.e., a log₂ fold change = ±0.4854). (D) Number of viral peptides in which positivity is associated with a higher (orange bars) or lower (blue bars) percentage of CD8⁺ senescent T cells (Wilcoxon P < 0.05).