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. 2023 Oct 26;63(6):136. doi: 10.3892/ijo.2023.5584

Figure 7.

Figure 7

Upregulation of ITGA4 expression is a signature of primary tumors with metastatic potential. (A) Representative images of ITGA4 expression in lung cancer for different nodal statuses. (B) ITGA4 expression was calculated as the mean intensity of staining per ITGA4-positive cells, and analyzed by one-way ANOVA with Tukey's multiple comparisons test. (C) ITGA4 expression at the primary site of N1 or N2 tumors compared with their corresponding lymph node metastases, as analyzed by two-way mixed ANOVA with the Bonferroni method for post hoc pairwise comparisons. (D) Representative images of ITGA4 expression in lung cancer at different stages. (E) ITGA4 expression in primary tumors at different cancer stages as analyzed by one-way ANOVA with Tukey's multiple comparisons test. (F) ITGA4 expression at the primary site of stage II or III tumors compared with their corresponding lymph node metastases, as analyzed by two-way mixed ANOVA with the Bonferroni method for post hoc pairwise comparisons. Magnification, x200. Upper scale bar, 200 µm; lower scale bar, 50 µm. *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001. ITGA4, integrin subunit α-4; M, matched lymph node metastatic site of the same tumor; N, nodal status.