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. 2023 Oct 25;14:1236374. doi: 10.3389/fimmu.2023.1236374

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Copyright © 2023 Westmeier, Brochtrup, Paniskaki, Karakoese, Werner, Sutter, Dolff, Limmer, Mittermüller, Liu, Zheng, Koval, Kaidashev, Berger, Herbstreit, Brenner, Witzke, Trilling, Lu, Yang, Babel, Westhoff, Dittmer and Zelinskyy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receptor and co-receptor positive Treg and convCD4⁺ T cells. Percentages of Treg and convCD4⁺ (conv) T cell subpopulations (A) from mildly (mild) or severely (sev) ill COVID-19 patients and healthy donors; frequencies of CD74⁺ Treg or convCD4⁺ T cells (B), CD44+ CD74+ Treg or convCD4⁺ T cells (C), CXCR2⁺ CD74⁺ Treg or convCD4⁺ T cells (D) and CXCR4⁺ CD74⁺ Treg or convCD4⁺ T cells (E) were analyzed by flow cytometry. Treg (CD127⁻ CD25⁺ CD4⁺) and convCD4⁺ T cells (CD127⁺ CD25⁻ CD4⁺) were characterized by using CD127 and CD25. Each dot represents an individual patient. Statistically significant differences are indicated by asterisks (* < 0.05; ** < 0.01; *** < 0.001; Kruskal-Wallis test with Dunn's multiple comparisons test).