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. 2023 Oct 25;14:1236374. doi: 10.3389/fimmu.2023.1236374

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Copyright © 2023 Westmeier, Brochtrup, Paniskaki, Karakoese, Werner, Sutter, Dolff, Limmer, Mittermüller, Liu, Zheng, Koval, Kaidashev, Berger, Herbstreit, Brenner, Witzke, Trilling, Lu, Yang, Babel, Westhoff, Dittmer and Zelinskyy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kinetics of CD74⁺ on convCD4⁺ and CD8⁺ T cells. PBMCs from COVID-19 patients were isolated on the first and seventh day of hospitalization. central memory (CM, CCR7⁺CD45RO⁺CD28⁺), effector memory (EM, CCR7⁻CD45RO⁺CD28⁻), and effector (E, CCR7-CD45RO⁻CD28⁻) CD8⁺ T cell subpopulations were characterized by using CD45RO, CCR7, and CD28. Frequencies of CD74⁺ convCD4⁺ T cell subpopulations (A–D) as well as CD8⁺ T cell subpopulations (E–H) were determined by flow cytometric analysis. Each dot represents an individual patient and lines connect values of an identical patient on day 1 and 7 of hospitalization. Mean values of are indicated by bars. Statistically significant differences between time points are indicated by asterisks (* < 0.05; ** < 0.01; *** < 0.001).