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Paromomycin exposure (AUC0–24) at last day of treatment (Day 14) in paediatrics (≤12 years) and adults (>12 years), compared with previously observed paromomycin exposure (Day 21) in adult Sudanese and Kenyan patients receiving 20 mg/kg/day paromomycin for 21 days (the marked area represents the IQR).8 One outlier patient with an extremely high AUC0–24 of 2388 µg × h/mL is not shown in this figure. This patient developed ototoxicity due to renal failure.
