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. 2023 Oct 9;55(11):1854–1865. doi: 10.1038/s41588-023-01522-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — In simulations at different levels of age-dependent effects (left), we report the AUPRC for ATM versus LDA as a function of subtype sample size proportion (the proportion of diagnoses belonging to the smaller subtype; right). Each dot represents the mean of 100 simulations of 10,000 individuals. Error bars denote 95% confidence intervals. a, Twenty-year difference in age at diagnosis for the two subtypes. b, Ten-year difference in age at diagnosis for the two subtypes. c, Five-year difference in age at diagnosis for the two subtypes. Numerical results are reported in Supplementary Table 2.