Fig. 4. Topic loadings in UK Biobank capture age-dependent comorbidities.

a, Age-dependent topic loadings for two representative topics, CER and CVD; for each topic, we include the top seven diseases with the highest topic loadings. Results for all ten topics are reported in Supplementary Fig. 9. b, Box plot of disease topic loading as a function of rank; disease topic loadings are computed as a weighted average across all values of age at diagnosis. c, Box plot of patient topic weight as a function of rank. Center, box bounds and whisker ends denote median, quartiles and minima/maxima. Numerical results are reported in Supplementary Table 5.