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. 2023 Oct 9;55(11):1854–1865. doi: 10.1038/s41588-023-01522-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Excess genetic correlations for pairs of 15 disease subtypes or diseases (nine disease subtypes (denoted with asterisks) + six diseases without subtypes), relative to genetic correlations between the underlying diseases. Full square with asterisk denotes FDR < 0.1; less than full squares have area proportional to z-scores for difference. Gray squares denote NA (pair of diseases without subtypes or pair of the same disease subtype or disease). b, Genetic correlations between the underlying diseases. Full circle denotes |z-score| > 4 for nonzero genetic correlation; less than full circles have area proportional to |z-score|. Numerical results are reported in Supplementary Table 14.