Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 21;270(12):5849–5865. doi: 10.1007/s00415-023-11862-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Fat replacement pattern in patients with mutations in the VCP gene. The figure shows the pattern of fat replacement observed in different patients with mutations in the VCP gene. A and B show normal cranial muscles without fat replacement. C shows fat replacement of the paraspinal cervical muscles (black arrow). D shows fat replacement of the paraspinal cervical muscles (black arrow) and trapezius (double arrow). E and F show a fat spot in the trapezius muscle (arrow) while scapular muscles are spared (double arrow). G shows fat replacement of the serratus anterior (black arrow) and the biceps brachii (double arrow). H, I and J show different examples of fat replacement in the trunk muscles, including abdominal (arrow) and paraspinal (double arrow) muscles. K shows involvement of the gluteus maximus (double arrow) and gluteus minimus (arrow) muscles, while gluteus medius (asterisk) is spared. L shows no involvement of the pelvic floor muscles (arrow). M shows characteristic involvement of upper thigh characterized by sparing of rectus femoris (arrow) and adductor longus (double arrow), with involvement of the vasti muscles (asterisk). N, O and P show different combinations of muscle fatty replacement observed in the thigh, N shows predominant posterior thigh involvement (arrow), while O and P show predominant anterior involvement (arrow) with sparing of rectus femoris (double arrow). R, S and T show different combinations of muscle fatty replacement observed in the leg, R shows fat replacement of gastrocnemius medialis (arrow) associated with asymmetric involvement of soleus (double arrow) and peroneus (asterisk). S shows involvement of the anterior (arrow) and posterior compartment (black arrow) and sparing of peroneus and tibialis posterior muscles (asterisk). T shows predominant anterior involvement (arrow) with sparing of soleus (asterisk)