Table 5.
Trimester-specific reference intervals (2.5–97.5th percentile) for thyroid function in pregnancy, in the present and previous longitudinal studies. Post-partum (PP) reference intervals obtained from the same subjects are also reported, when available
| Author, year publ (Refs.) | Method | TSH (mU/L) | FT4 (pmol/L) | FT3 (pmol/L) | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1st | 2nd | 3rd | PP | 1st | 2nd | 3rd | PP | 1st | 2nd | 3rd | PP | |||||||||||||||
| LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | LRL | UPR | |||
| Present study | Roche Elecsys | 0.34 | 3.81 | 0.68 | 4.07 | 0.63 | 4.00 | 0.56 | 3.42 | 11.40 | 17.40 | 9.98 | 15.25 | 9.49 | 15.1 | 11.9 | 19.3 | 3.88 | 6.05 | 3.61 | 5.38 | 3.59 | 5.37 | 4.2 | 6.5 | |
| Sekhri et al. 2016 [13] | Roche Elecsys | 0.09 | 6.65 | 0.51 | 6.66 | 0.91 | 4.86 | – | – | 9.81 | 18.53 | 8.52 | 19.43 | 7.39 | 18.28 | – | – | 3.1 | 6.35 | 2.39 | 5.12 | 2.57 | 5.68 | – | – | |
| Joosen et al. 2016 [14] | Roche Elecsys | 0.11 | 3.39 | 0.25 | 3.38 | 0.51 | 3.85 | 0.53 | 2.92 | 11.70 | 20.00 | 9. .3 | 14.2 | 8.1 | 14.9 | 10.8 | 18.2 | – | – | – | – | – | – | – | – | |
| Ortega Carpio et al. 2018 [15] | Roche Elecsys | 0.25 | 4.68 | 0.62 | 4.83 | 0.76 | 4.57 | – | – | 12.20 | 20.20 | 12 | 16.9 | 9 | 16.3 | – | – | – | – | – | – | – | – | – | – | |
| Kostecka-Matyja et al. 2017 [16] | Roche Elecsys | 0.01 | 3.18 | 0.05 | 3.44 | 0.11 | 3.53 | – | – | 11.99 | 21.89 | 10.46 | 16.67 | 8.96 | 17.23 | – | – | 3.63 | 6.55 | 3.29 | 5.45 | 3.1 | 5.37 | – | – | |
| Yuen et al. 2020 [17] | Roche Elecsys | 0.06 | 3.14 | 0.15 | 3.78 | 0.31 | 4.54 | – | – | 11.20 | 22.20 | 10.1 | 19.4 | 9 | 17 | – | – | 3.47 | 5.66 | 3.25 | 5.2 | 2.94 | 4.56 | – | – | |
| Yuen et al. 2020 [17] | Siemens Centaur | 0.03 | 2.5 | 0.08 | 2.93 | 0.25 | 3.9 | – | – | 11.9 | 20.2 | 11.3 | 18.7 | 10.1 | 16 | – | – | 3.63 | 5.73 | 3.39 | 5.26 | 3 | 4.52 | – | – | |
| Yuen et al. 2020 [17] | Beckman DXI | 0.11 | 2.71 | 0.19 | 3.25 | 0.3 | 3.87 | – | – | 8.20 | 14.40 | 7.4 | 12.6 | 6.7 | 11 | – | – | 4.04 | 6.14 | 3.85 | 5.75 | 3.57 | 5.18 | – | – | |
| Ekinci et al. 2013 [18] | Beckman DXI | 0.03 | 3.05 | 0.42 | 3.36 | 0.34 | 2.83 | 0.25 | 2.55 | 5.90 | 15.50 | 4.9 | 11.3 | 4.5 | 11.20 | 4.5 | 14.4 | 3.90 | 5.7 | 3.7 | 5.2 | 3.5 | 5 | 3.8 | 6 | |
| Yuen et al. 2020 [17] | Abbott Architect | 0.04 | 2.11 | 0.1 | 2.51 | 0.19 | 2.99 | – | – | 11.20 | 19.00 | 10.5 | 17.1 | 9.5 | 14.7 | – | – | 3.45 | 5.52 | 3.39 | 5.41 | 3.22 | 5.12 | – | – | |
| Ho et al. 2017 [19] | Abbott Architect | 0.01 | 2.88 | 0.33 | 3.33 | 0.3 | 3.05 | – | – | 11.4 | 19.50 | 10.1 | 15.5 | 8.9 | 14.7 | – | – | 4.26 | 6.35 | 4.15 | 6.13 | 3.66 | 6.1 | – | – | |
| Ho et al. 2017 [19] | Abbott Architect | 0.02 | 2.45 | 0.35 | 3.64 | 0.52 | 3.43 | – | – | 11.6 | 19.30 | 10 | 14.8 | 8.9 | 14.4 | – | – | 4.24 | 7.06 | 4.03 | 6.32 | 3.72 | 6.17 | – | – | |
| Ho et al. 2017 [19] | Abbott Architect | 0.02 | 2.21 | 0.26 | 2.96 | 0.35 | 3.48 | – | – | 11.2 | 19.7 | 10.1 | 15.5 | 8.7 | 14.7 | – | – | 3.97 | 6.49 | 4.16 | 6.25 | 3.48 | 6.15 | – | – | |
| Ollero et al. 2019 [20] | Abbott Architect | 0.13 | 4.16 | 0.31 | 3.73 | 0.58 | 4.36 | – | – | 10.94 | 15.96 | 10.55 | 15.44 | 8.62 | 13.64 | – | – | – | – | – | – | – | – | – | – | |
Bold indicates data of the present study