Table 3.
Diagnostic performance of different thresholds of κFLC index and IgG OCB for the diagnosis of MS/CIS in our study population (607 patients)
| Se, % (95% CI) | Sp, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | J | AUC (95% CI) | |
|---|---|---|---|---|---|---|
| 4.25 | 86.8 (83.8–89.3) | 88.1 (85.2–90.6) | 87.4 (84.4–89.9) | 87.6 (84.6–90.0) | 0.75 | 0.875 (0.844–0.905) |
| 5.00 | 85.4 (82.3–88.1) | 90.4 (87.7–92.6) | 89.4 (86.6–91.6) | 86.8 (83.8–89.3) | 0.76 | 0.879 (0.849–0.909) |
| 5.90 | 82.0 (78.7–85.0) | 92.0 (89.5–94.0) | 90.6 (88.0–92.8) | 84.4 (81.2–87.2) | 0.74 | 0.870 (0.839–0.901) |
| 6.60 | 80.0 (76.5–83.1) | 92.9 (90.5–94.8) | 91.5 (88.9–93.5) | 83.1 (79.8–85.9) | 0.73 | 0.865 (0.833–0.869) |
| 7.83 | 78.0 (74.4–81.2) | 93.6 (91.3–95.3) | 92.0 (89.5–94.0) | 81.8 (78.4–84.7) | 0.72 | 0.858 (0.825–0.890) |
| 10.5 | 71.9 (67.4–76.0) | 94.9 (92.7–96.5) | 93.0 (90.6–94.8) | 78.1 (74.6–81.3) | 0.67 | 0.834 (0.799–0.868) |
| 11.0 | 73.2 (68.3–77.7) | 95.5 (93.1–97.1) | 90.3 (87.3–92.7) | 86.1 (82.7–89.0) | 0.69 | 0.832 (0.797–0.866) |
| 12.3 | 69.2 (65.3–72.8) | 96.2 (94.2–97.5) | 94.4 (92.2–96.1) | 76.7 (73.1–80.0) | 0.65 | 0.827 (0.791–0.862) |
| IgG OCB | 72.2 (68.4–75.7) | 95.2 (93.1–96.7) | 93.4 (91.1–95.2) | 78.4 (74.8–81.5) | 0.67 | 0.84 (0.80–0.87) |
κFLC kappa free light chains, OCB oligoclonal bands, MS multiple sclerosis, CIS clinically isolated syndrome, Se sensitivity, Sp specificity, VPP positive predictive value, NPV negative predictive value, J Youden’s index, AUC area under the curve, CI confidence interval