Table 6.
Sensitivity and specificity values for different thresholds of κFLC index reported in previous studies and characteristics of the study cohorts
| Cut-off | Sensitivity | Specificity | Patients | Cases | McDonald’s criteria | |
|---|---|---|---|---|---|---|
| ≥ 4.25 | 94% | 100% | 137 | MS (70) | 2017 | Puthenparampil et al. (2018) |
| ≥ 5 | 96% | 78% | 385 | MS (127) | 2017 | Crespi et al. (2019) |
| ≥ 5.9 | 96% | 86% | 438 | CIS/MS (70) | 2010 | Presslauer et al. (2016) |
| ≥ 6.6 | 93% | 83% | 745 | CIS, MS (526) | 2010 | Leurs et al. (2019) |
| ≥ 7.83 | 89% | 81% | 170 | RIS, CIS, MS (64) | 2010 | Gaetani et al. (2020) |
| ≥ 10.5 | 87% | 76% | 320 | RIS, CIS, MS (67) | 2010 | Gurtner et al. (2018) |
| ≥ 12.3 | 93% | 100% | 176 | MS (71) | 2010 | Pieri et al. (2017) |
MS multiple sclerosis, CIS clinically isolated syndrome, RIS radiologically isolated syndrome