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. 2023 Nov 8;12:35. doi: 10.1186/s13619-023-00179-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Histone modifications profiles of the discordant genes. A Heatmaps of ATAC signals (left), H3K4me3 signals (middle) and H3K27ac signals (right) for the discordant upregulated genes (upstream 3 kb and downstream 3 kb of the peaks). Loci were clustered by the k-means algorithm based on the signal profile and arranged by the average signal strength. B Pileups of mean ATAC signals (first panel), mean H3K4me3 signals (second panel), mean H3K27ac signals (third panel) and mean RNA signals (fourth panel) for the genes within cluster 1 and cluster 2 showed in Fig. 3 A (upstream 3 kb and downstream 3 kb of the peaks or transcripts with merged exons). C Heatmaps of ATAC signals (left), H3K4me3 signals (middle) and H3K27ac signals (right) for the discordant downregulated genes (upstream 3 kb and downstream 3 kb of the peaks). Loci were clustered by the k-means algorithm based on the signal profile and arranged by the average signal strength. D Pileups of mean ATAC signals (first panel), mean H3K4me3 signals (second panel), mean H3K27ac signals (third panel) and mean RNA signals (fourth panel) for the genes within cluster 1 and cluster 2 showed in Fig. 3C (upstream 3 kb and downstream 3 kb of the peaks or transcripts with merged exons). E ATAC signals (first panel), RNA signals (second panel), H3K4me3 signals (third panel) and H3K27ac signals (fourth panel) for the representative loci within cluster 1 and cluster 2 showed in Fig. 3A. F ATAC signals (first panel), RNA signals (second panel), H3K4me3 signals (third panel) and H3K27ac signals (fourth panel) for the representative loci within cluster 1 and cluster 2 showed in Fig. 3C