Table 2.

Sensitivity analysis of the causal associations between PA/SBs on OA and total joint arthroplasty.

Exposure	Outcome	Nsnp	Cochran's Q test		MR-Egger regression		MR PRESSO		Steiger test
			Q	P value	Egger intercept	P value	Global.Test	P value	Direction	P value
Light DIY	Overall OA	12	22.964	0.191	0.008	0.148	25.886	0.341	True	7.23 × 10–7
Light DIY	Knee OA	12	22.102	0.485	0.002	0.451	24.778	0.597	True	6.25 × 10–3
Walking for pleasure	Overall OA	20	50.437	1.19 × 10–8	− 0.001	0.343	71.158	0.124	True	1.72 × 10–4
Walking for pleasure	Knee OA	20	13.583	0.226	0.004	0.602	18.366	0.316	True	5.02 × 10–3
Television watching	Overall OA	151	248.971	6.86 × 10–7	0.002	0.758	26.434	0.112	True	5.77 × 10–4
Television watching	Knee OA	151	174.243	0.085	− 0.012	0.146	19.671	0.149	True	1.48 × 10–4
Television watching	Hip OA	151	339.631	9.86 × 10–17	− 0.007	0.201	35.474	0.071	True	1.17 × 10–4
Television watching	TKA	147	209.871	6.18 × 10–5	− 8.46 × 10–5	0.558	22.991	0.121	True	7.32 × 10–3

MR Mendelian randomization, OA osteoarthritis, TKA total knee arthroplasty, IVW inverse-variance weighted, MR PRESSO MR Pleiotropy RESidual Sum and Outlier, OR odds ratio, CI confidence interval.