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. 2023 Nov 8;14:7211. doi: 10.1038/s41467-023-42881-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A T-distributed stochastic neighbor embedding (tSNE) based on lineage/inflammatory markers (indicated in Supplementary Table 3) was used to visualize multidimensional separation of Oligomycin-treated circulating myeloid/DC subtype populations from HD and melanoma patients. B Box plots represent differences in SCENITH metabolic parameters in circulating myeloid/DC subtypes between heathy donor (HD, n = 3) vs. good (PR/NED1/SD, n = 13) and bad (PD/NED2, n = 17) response groups. Pairwise comparisons against a HD reference group in were calculated using Two-tailed Student’s t-test with Holm-Bonferroni correction. C Box plots represent comparisons of median MFI expression profiles for circulating myeloid/DC subtype populations between glycolytic (red) and mitochondrial-dependent (blue) oligomycin quantiles (n = 30). In B, C Box plots indicate 1st, 2nd and 3rd quartile; whiskers indicate minimum and maximum. Statistical significance between outcome groups was determined using Two-tailed Student’s t-tests. Source data are provided as a Source Data file.