Table 2.

Cytogenetics of primary and relapsed/refractory ML-DS blasts.

Cytogenetic abnormalities		Primary ML-DS (n = 31)	Relapsed/refractory ML-DS (n = 31)
Trisomy 8		8	10
Trisomy 21, acquired		6	6
Chromosome 17	Monosomy 17	0	5
	del(17p)	0	2
Chromosome 7	Monosomy 7	3	4
	i(7)(q10)	3	4
	del(7p)	1	1

Among 31 patients who had paired karyotypes available from both time-points, 18 gained abnormalities, 2 lost abnormalities, and 11 showed no change at the time of diagnosis of r/r ML-DS compared to those at the primary diagnosis. The table summarizes the subset of changes present in more than 1 patient.