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. 2023 Oct 10;19(11):e11670. doi: 10.15252/msb.202311670

Figure 2. Neighbor dependent‐genes identified by CellNeighborEX in mouse hippocampus Slide‐seq data.

Figure 2

  1. The heterotypic spots of Endothelial tip and Astrocyte cells (EnT + A) (n = 121) were compared with the respective homotypic spots (EnT [n = 60], Astrocyte [n = 2,909]; log ratio > 0.4, P‐value < 0.01) and additionally with the artificial heterotypic spots (FDR < 0.01). The statistical test was chosen among the two tailed Student's t‐test, Welch's t‐test, or Wilcoxon rank sum test depending on the sample size and heterogeneity of variance test. The volcano plot displays 3 up‐regulated genes including Fabp7. In the heatmap, the genes are more highly expressed in EnT + A. The heterotypic spots also express both EnT and Astrocyte markers.
  2. The spatial visualization shows the higher expression level of Fabp7 in EnT + A.
  3. In the mouse hippocampus scRNA‐seq data, Fabp7 is mostly expressed in Astrocyte.
  4. In GO analysis, the GO terms are related to neuronal regulation. The bar plot presents top 20 GO terms.