Table 2.
Association between patient and disease characteristics and preference for active surveillance, univariate and multivariable logistic regression analyses.
| Variable | n women | Univariate OR (95% CI) |
p-value | Multivariable OR (95% CI) |
p-value |
|---|---|---|---|---|---|
| Age at diagnosis | 1.02 (1.00–1.06) | 0.102 | 1.01 (0.97–1.04) | 0.683 | |
| DCIS-grade | |||||
| Grade 1 | 126 | 1.00 (ref) | 1.00 (ref) | ||
| Grade 2 | 146 | 1.01 (0.59–1.74) | 0.976 | 1.07 (0.60–1.91) | 0.818 |
| Unknown Gradea | 105 | 1.72 (0.90–3.27) | 0.101 | 2.25 (0.76–6.65) | 0.141 |
| DCIS-size | |||||
| < 20 mm | 190 | 1.00 (ref) | 1.00 (ref) | ||
| 20–49 mm | 45 | 0.83 (0.40–1.71) | 0.618 | 0.88 (0.40–1.94) | 0.744 |
| > 49 mm | 13 | 1.86 (0.40–8.69) | 0.431 | 2.19 (0.38–12.63) | 0.380 |
| Unknown Sizea | 129 | 1.34 (0.78–2.30) | 0.290 | 0.80 (0.30–2.15) | 0.662 |
| Educational levelb | |||||
| Low | 130 | 1.00 (ref) | 1.00 (ref) | ||
| Moderate | 114 | 0.53 (0.28–1.01) | 0.052 | 0.64 (0.31–1.33) | 0.232 |
| High | 133 | 0.42 (0.23–0.77) | 0.005 | 0.45 (0.22–0.93) | 0.030 |
| Trust in oncologist | |||||
| Little trust | 21 | 1.00 (ref) | 1.00 (ref) | ||
| Much trust | 327 | 2.95 (1.21–7.21) | 0.018 | 2.16 (0.81–5.75) | 0.124 |
| Neutral | 29 | 12.27 (2.31–63.34) | 0.003 | 9.08 (1.61–51.22) | 0.012 |
| Decision made by | |||||
| Patient | 244 | 1.00 (ref) | 1.00 (ref) | ||
| Oncologist | 5 | 1.51 (0.17–13.80) | 0.713 | 0.95 (0.08–10.7) | 0.967 |
| Together | 99 | 2.50 (1.31–4.79) | 0.005 | 2.71 (1.37–5.37) | 0.004 |
| Otherc | 29 | 0.99 (0.42–2.35) | 0.954 | 0.87 (0.34–2.18) | 0.759 |
| Tolerance of uncertainty | |||||
| High tolerance | 278 | 1.00 (ref) | 1.00 (ref) | ||
| Low Tolerance | 99 | 0.89 (0.52–1.51) | 0.654 | 0.87 (0.47–1.60) | 0.651 |
| HADS anxiety score | |||||
| Not elevated | 317 | 1.00 (ref) | 1.00 (ref) | ||
| Elevated | 60 | 0.61 (0.33–1.12) | 0.111 | 0.60 (0.29–1.24) | 0.168 |
| Risk perceptiond | |||||
| Equal | 146 | 1.00 (ref) | 1.00 (ref) | ||
| Lower | 11 | 3.40 (0.42–27.42) | 0.252 | 4.71 (0.52–42.4) | 0.167 |
| Higher | 206 | 1.21 (0.74–2.00) | 0.445 | 1.42 (0.83–2.44) | 0.206 |
| Don’t know | 14 | 0.45 (0.15–1.39) | 0.166 | 0.55 (0.15–1.97) | 0.360 |
Abbreviations: n, number; OR, Odds Ratio; CI, Confidence Interval; DCIS, Ductal Carcinoma In Situ; HADS, Hospital Anxiety and Depression Scale.
Not yet registered in trial database.
Educational level was categorised in three levels: low level (i.e. elementary school, secondary vocational education), moderate level (i.e. high school, post-secondary vocational education) and high level (i.e. higher vocational education or university).
Other was accompanied by open-ended question, most reported including family and friends in the decision-making process.
Perception of breast cancer risk compared to other women of the same age who did not have DCIS.