. 2023 Nov 1;20(11):1633–1641. doi: 10.1513/AnnalsATS.202303-248OC

Table 4.

Associations of HBs with CVD mortality in all adjusted models

Model^*	n	HB OR (95% CI)	HB_Oxi OR (95% CI)
Model 1	4,925	1.17 (1.03–1.32)^†	1.15 (1.02–1.29)^†
Model 2	4,895	1.19 (1.04–1.36)^‡	1.18 (1.04–1.34)^‡
Model 3	4,779	1.16 (1.01–1.32)^†	1.15 (1.01–1.30)^†

Definition of abbreviations: CI = confidence interval; CVD = cardiovascular disease; HB_Oxi = oximetry-derived hypoxic burden; OR = odds ratio; Sp_O₂ = oxygen saturation as measured by pulse oximetry.

HBs were based on manually scored events and automatically identified desaturations; HB_Oxi was based on ⩾2% desaturations. Odds ratios are expressed per 1–standard deviation increase in log-transformed HBs. CVD mortality was based on the underlying cause of death assessed by a study physician adjudicator. A CVD cause of death was broadly categorized by International Classification of Diseases, 9th Revision codes as CVD (codes 396.9–442, 966.71, and 785.51).

Model 1 was adjusted for age, sex, and race. Model 2 was adjusted for age, sex, race, body mass index, smoking status, and wakefulness Sp_O₂. Model 3 was adjusted for age, sex, race, body mass index, smoking status, wakefulness Sp_O₂, diabetes, heart failure, angina, myocardial infarction, and stroke.

^{^†}

P < 0.05.

^{^‡}

P < 0.01.