Table 3.
Definitions of SSc-ILD progression based on the combination of multiple parameters
| SSc mixed cohorts | SSc-ILD cohorts | ||||||||
| Time, months (n papers) |
n patients (n papers) | n ILD patients (n papers) | n progressors (n papers) |
References | Time frame, months (n papers) |
n patients (n papers) | n progressors (n papers) | References | |
| PFTs | |||||||||
| Decline FVC>10% or DLCO>15% | 6 (1) 12 (6) 24 (3) >36 (5) >60 (1) Unk (6) |
10 476 (18) | 4258 (14) | 1144 (14) | 8 70 116 117 148 208 213–225 | 6 (1) 12 (9) 24 (4) 36 (1) >60 (3) Unk (8) |
1571 (22) | 461 (18) | 32 38 123 152 153 226–241 |
| Decline FVC>10% or DLCO>10% | 6 (1) 12 (2) >36 (4) 60 (1) |
531 (8) | 336 (8) | 181 (8) | 174 205 242–245 | 12 (1) 24 (1) 36 (2) >36 (2) |
489 (6) | 47 (4) | 121 246–250 |
| Decline FVC>10% and/or decline FVC 5%–9% with decline DLCO>15% | 6 (1) 12 (2) 24 (1) |
878 (4) | 495 (4) | 110 (4) | 251–254 | 12 (2) Unk (1) |
772 (3) | 96 (1) | 154 192 255 |
| PFTs+HRCT | |||||||||
| Decline FVC≥10% or DLCO≥15% or ILD extent increase>20% | 12 (1) 21 (1) 24 (1) |
462 (3) | 204 (3) | 55 (3) | 113 256 257 | 12 (1) 56 (1) |
72 (2) | 15 (2) | 258 |
| PFTs or HRCT+clinical signs | |||||||||
| Decline FVC>10% or decline FVC 5%–10% and worsening f respiratory symptoms or/and increase ILD extent |
24 (1) | 36 (1) | 22 (1) | 9 (1) | 259 | 12 (1) 36 (1) Unk (1) |
109 (3) | 48 (1) | 260–262 |
DLCO, carbon monoxide diffusing capacity; FVC, forced vital capacity; HRCT, high-resolution CT; ILD, interstitial lung disease.