Table 4.
Definitions of outcome in SSc-ILD
| SSc mixed cohorts | SSc-ILD cohorts | ||||||||
| Time, months (n papers) |
n patients (n papers) | n ILD patients (n papers) | n of patients with outcome (n papers) | References | Time, months (n papers) |
n patients (n papers) | n of patients with outcome (n papers) | References | |
| Mortality due to ILD | 180 (12) | 6165 (12) | 2628 (10) | 277 (12) | 23 24 65 118 138 167 263–267 | – | – | – | – |
| SSc-related mortality | 25- 200 (7) UNK (1) |
3789 (7) | 1785 (7) | 324 (7) | 23 65 264 266 268 269 | 97 (1) | 306 (1) | 39 (1) | 17 |
| 15-year mortality | – | 1284 (1) | 522 (1) | 260 (1) | 270 | – | 106 (1) | 21 (1) | 154 |
| 10-year mortality | – | 7484 (13) | 2509 (10) | 1991 (13) | 23 78 106 111 130 179 214 267 268 271–273 | – | 223 (3) | 46 (3) | 144 150 274 |
| 5-year mortality | – | 10 604 (16) | 4335 (15) | 1104 (13) | 23 84 106 111 173 225 242 267 268 271–273 275–277 | – | 436 (6) | 117 (6) | 274 278–282 |
| 3-year mortality | – | 1046 (5) | 688 (5) | 134 (5) | 158 173 242 268 275 | – | 264 (5) | 25 (5) | 127 152 279 281 283 |
| 1-year mortality | – | 1153 (5) | 633 (5) | 33 (2) | 254 268 272 273 275 | – | 314 (8) | 12 (6) | 280–287 |
| Mortality | 12–36036 | 23 366 (35) | 5048 (26) | 2338 (31) | 5 8 23 25 64–66 92 114 117–119 131 147 160 174 177 219 244 266–268 288–300 | 12–348 (32) | 3028 (31) | 582 (27) | 17 28 50 71 85 128 141 142 149 151 153 163 170 185 226 238 242 258 269 274 278 301–311 |
| In-hospital mortality | 120 (1) 12 (1) Unk (3) |
14 240 (4) | 1899 (3) | 164 (3) | 312–316 | – | – | – | – |
| Mortality after lung transplantation | 45–721 | 72 (1) | 27 (1) | 317 | |||||
| Hospitalisation | 12 (1) 120 (2) 84 (1) Unk (3) |
6211 (5) | 1261 (4) | 591 (4) | 312 314 316 318 319 | 12 (1) | 574 (1) | 78 (1) | 166 |
| End-stage ILD | 12 (1) 60 (1) 120 (1) 200 (2) |
1646 (5) | 451 (4) | 111 (5) | 65 245 320–322 | 173 (1) | 50 (1) | 16 (1) | 323 |
| Lung transplantation | 120 (1) 200 (1) | 552 (2) | 203 (2) | 17 (2) | 65 179 | 60 (1) | 172 (1) | 3 (1) | 301 |
| Infections | 120 (1) | 95 (1) | 36 (1) | 26 (1) | 312 | 120 (1) | 46 (1) | 9 (1) | 144 |
ILD, interstitial lung disease; SSc, systemic sclerosis; Unk, unknown/not specified.