. 2010 Jan 20;2010(1):CD007046. doi: 10.1002/14651858.CD007046.pub2

Andre 2007.

Methods	RCT(minimization). 2X2 factorial design
Participants	surgically resected colorectal cancer
Interventions	6 months treated versus 9 months LV5FU 2 (5FU bolus 400 mg/m² then 600 mg/m² for 22h d1, d2) every 2 weeks versus FULV each month d1‐d5, 400mg/m²
Outcomes	RFS and OS
Notes
*Risk of bias*
Bias	Authors' judgement	Support for judgement
Blinding?   All outcomes	High risk
Incomplete outcome data addressed?   All outcomes	Low risk	Intention to treat (ITT) analysis.
Free of other bias?	Low risk