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. 2023 Nov 9;13(47):33080–33095. doi: 10.1039/d3ra06189b

Scheme 1. Synthesis of 2-substituted-quinoxaline analogues bearing phenyl or coumarin moiety (3a, b-5). Regents and conditions: (a) Br2, glacial AcOH, 60 °C-r. t., 12 h; (b) o-phenylene diamine, sodium acetate, EtOH, reflux, 12 h; (c) acetic anhydride, reflux, 14 h; (d) bromine, acetic acid, reflux, 8 h.

Scheme 1