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. 2023 Nov 9;42:295. doi: 10.1186/s13046-023-02823-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PINK1 is associated with poor prognosis of ovarian cancer. A The correlation between autophagy-related kinase and ovarian cancer patients’ prognosis. B The Hazard Ratio (HR) and 95% confidence interval (CI) of the significant correlation between autophagy-related kinase with ovarian cancer patients’ prognosis. C Forest plot of Hazard Ratios for evaluating the association between PINK1 expression and overall survival of ovarian cancer patients. The data included was obtained from Kaplan–Meier website and was stratified based on PINK1 expression. The red dotted line represents the pooled HR of meta-analysis. D A Kaplan–Meier plot was used to display overall survival curves of ovarian cancer patients from a local cohort stratified based on PINK1 expression levels. E The correlation between PINK1 expression and CA125 serum level. F The correlation between PINK1 expression and ascites volume. G Association between PINK1 expression and clinicopathological features. H Western blot analysis for PINK1 protein levels in six paired primary and metastatic ovarian cancer tissues. I Representative images of immunohistochemistry (IHC) staining depicting the expression of PINK1 in human samples of ovarian carcinoma in primary and metastatic tissue. J Score of IHC staining against PINK1 in paired primary and metastatic ovarian cancer specimens. * p < 0.05. Values are mean ± SEM. Data are representative of 3 independent experiments