Fig. 6.

PINK1 promotes the metastasis of ovarian cancer and cisplatin resistance via regulating PTEN. A Schematic diagram of animal experiment procedure. B Knock down efficiency of shRNA targeting PINK1 evaluated by western blot and qRT-PCR. C Representative images of metastatic nodules in the abdomens of nude mice injected with SKOV3 cells stably expressing an empty vector or PINK1-targeting shRNAs, and administered DDP. D The metastatic tumors were separated and recorded. E and F Quantitative analysis of the number (E) and weight (F) of metastatic tumors in mice. G and H Representative images (G) and quantitative analysis (H) of IHC staining of CA125, Ki67, LDHA, E-cadherin and vimentin proteins. I Western blot detection of indicated protein expression levels in metastatic nodules located in the abdomens of nude mice subjected to specific treatments. * p < 0.05, ** p < 0.01, and **** p < 0.0001. Values are mean ± SEM. Data are representative of 3 independent experiments