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USP7 inhibitor upregulated c-Myc in cancer cells via USP22-dependent way. Western blot analysis of elevated c-Myc in A. A549 and B. HCT116 cancer cells treated with defined amounts of FT671 for 72h. C. FT671 treatment increased c-Myc-responsive luciferase reporter activity in H1299 cells in a dose-dependent manner, *p<0.05, ** p<0.01, compared to 0 (Vehicle). D. Western blot analysis of FT671-induced c-Myc in the parental (Wt) and USP22-Ko (Ko) H1299 cancer cells
