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. 2023 Nov 9;21:319. doi: 10.1186/s12964-023-01320-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — USP7 inhibitor decreased H2Bub1 in USP22+/+ cells and further enhanced p53 activation in USP22-Kd cancer cells. A. Impact of FT671 treatment on H2Bub1 in the parental and USP22-Kd HCT116 cancer cells. B. Western blot analysis of Sirt1-P53-P21 in the parental (USP22+/+) and USP22-Ko (USP22-/-) A549 cells treated with FT671