Fig. 6.

USP7 inhibitor PD5091 suppressed in vivo growth of USP22-Ko A549 cancer cells. A. In vivo growth curves of these two xenografts treated with vehicle or P5091 (Wt: parental A549; Ko: USP22-Ko-A549). B. Cancer xenograft images C. Cancer xenograft weights of A549 and USP22-Ko A549 lung cancer cells treated with USP7 inhibitor P5091, *p<0.05, ** p<0.01, compared to Vehicle. D. Western blot analysis of USP22, MDM2 in A549 and USP22-Ko-A549 lung cancers treated with USP7 inhibitor P5091