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. 2023 Nov 9;12:50. doi: 10.1186/s40035-023-00384-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Cytokine and growth factor analysis of iPSC-derived CNSC-SE. a Human cytokine array images of CNSC and iPSC conditioning media and quantification. b Human growth factor array images for CNSC-SE and MSC-SE. c Relative expression of IGFBP-2, IGF-2 and IGF-1r in 5×FAD brain. d Quantitative assessment of hippocampal area by Cresyl violet staining. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 (T-test). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. AD (One-way ANOVA)