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. 2023 Sep 21;8(20):e169344. doi: 10.1172/jci.insight.169344

Figure 4. XIST expression in PBMCs correlates with SLE status and disease activity.

Figure 4

RNA flow cytometry was used to measure XIST and Rpl13A expression levels in PBMCs from women with SLE (n = 11) versus healthy women (n = 12). (A and B) Dot plots showing XIST (A) and RPL13A (B) MFI in SLE and control PBMCs. Healthy controls are also shown in Supplemental Figure 3C. (C–E) XIST MFI in B cells (C), T cells (D), and monocytes (E) from patients with SLE and controls. (F) Bar graph showing XIST MFI in SLE patients with a PGA ≥ 1 (n = 7) and a PGA < 1 (n = 4). (G) Scatterplot of XIST MFI versus SLEDAI. Pearson’s correlation coefficient and P value for linear regression shown. (A–E) * indicates P < 0.05, and ** indicates P < 0.01. Error bars indicate 1 standard deviation. (A–F) Expression of XIST or RPL13A compared between patients with SLE and healthy donors (A–E) or disease groups (F) by t test. (G) Correlation tested by simple linear regression.