Figure 5.

Cartoon illustrating the positive regulatory functions of m⁶A on the efficacy of long-term memory formation. Behavior training will induce gene expression in mouse hippocampus. Such learning-based gene activation is essential for the brain to reshape its neural network to encode new information as memory. After learning stimulation, m⁶A modifications would be added to transcripts of learning-induced genes and further enhance mRNA translation, neural network long-term potentiation, and the efficacy of mouse long-term memory formation.