Table 2.

Overall survival analysis by comorbidity group in patients with advanced HNC

	OS HR (95% CI)
Variable	Unadjusted	P value	Adjusteda	P value
Age
< 50 years	[Reference]		[Reference]
50–59 years	0.41 (0.17, 1.03)	0.06	0.28 (0.06, 1.30)	0.10
60–69 years	0.39 (0.17, 0.87)	0.02	0.18 (0.04, 0.76)	0.02
70–79 years	0.33 (0.13, 0.81)	0.02	0.14 (0.03, 0.68)	0.01
≥ 80 years	0.12 (0.01, 0.92)	0.04	0.04 (0.00, 0.50)	0.01
Sex
Male	[Reference]		[Reference]
Female	0.81 (0.34, 1.9)	0.62	1.24 (0.31, 5.02)	0.76
Race
White	[Reference]		[Reference]
Other	1.02 (0.55, 1.9)	>0.9	0.62 (0.24, 1.63)	0.33
HPV Status
HPV-Negative	[Reference]		[Reference]
HPV-Positive	1.40 (0.67, 2.92)	0.38	1.03 (0.24, 4.33)	>0.9
Comorbidity
CCI < 1	[Reference]		[Reference]
CCI ≥ 1	1.55 (0.88, 2.74)	0.13	2.74 (1.18, 6.40)	0.02
Primary Site
Non - Oropharynx	[Reference]		[Reference]
Oropharynx	1.12 (0.63, 1.97)	0.70	1.47 (0.42, 5.17)	0.55
BMI Group
Non-Obese	[Reference]		[Reference]
Obese	0.45 (0.18, 1.13)	0.09	0.31 (0.08, 1.24)	0.10
Smoking Status
Non-Smoker	[Reference]		[Reference]
Smoker	1.08 (0.61, 1.93)	0.79	1.57 (0.65, 3.76)	0.32

Note: Bold values are statistically significant.

^aAdjusted by age, sex, race, HPV status, primary site, BMI, and smoking status.