Table 1.
Regulatory element of NLRP3-mediated pyroptosis in arthritis.
| Diseases | Regulatory element | Possible upstream or downstream pathways | Target cells | Animal models | Ref |
|---|---|---|---|---|---|
| OA | UPS7 | NOX4/ROS/NLRP3 | Chondrocyte | Rat | (37) |
| P2X7 | NF-κB/NLRP3/Caspase-1 | Chondrocyte | Rat | (34) | |
| Morroniside | NF-κB/NLRP3/Caspase-1 | Chondrocyte | Mice | (32) | |
| Loganin | NF-κB/NLRP3/Caspase-1 | Chondrocyte | Mice | (51) | |
| ICA | NLRP3/Caspase-1 | Chondrocyte | Rat | (52) | |
| Dietary fatty acid | TLR4/NF-κB/NLRP3/Caspase-1 | Chondrocyte | Mice | (36) | |
| CY-09 | NLRP3/Caspase-1 | Chondrocyte | Mouse | (53) | |
| CF101 | ROS/NLRP3/Caspase-1 | Chondrocyte | Rat | (31) | |
| Lico A | Nrf2/HO-1/NF-κB/NLRP3 | Chondrocyte | Mice | (35) | |
| HIF-1α | NLRP3/Caspase-1 | FLSs | Rat | (54) | |
| SDF-1 | AMPK/NLRP3/Caspase-1 | FLSs | Rat | (55) | |
| MCC950 | NLRP3/Caspase-1 | Macrophage | Rat | (33) | |
| RA | HQH | NLRP3/Caspase-1 | / | Rat | (56) |
| ASIC1a | NLRP3/Caspase-1 | Chondrocyte | Rat | (39) | |
| ASIC1a | calpain-2/calcineurin/NLRP3/Caspase-1 | Chondrocyte | / | (57) | |
| Punicalagin | NF-κB/NLRP3/Caspase-1 | Macrophage | Mice | (41) | |
| A20 | NLRP3/Caspase-1 | Macrophage | Mice | (43) | |
| Pol β | cGas/STING/NF-κB/NLRP3 | Macrophage | Mice | (58) | |
| BHGZD | TLR4/PI3K/AKT/NF-κB/NLRP3 | Macrophage | Rat | (38) | |
| MDP | ROS/GRK2/HIF-1α/NLRP3 | FLSs | Rat | (42) | |
| LPS | NF-κB/NLRP3/caspase-1/GSDMD | FLSs | / | (59) | |
| JWJG Capsule | NLRP3/caspase-1 | FLSs | / | (60) | |
| C1q and PTX3 | NLRP3/caspase-1 | Monocyte | / | (61) | |
| GA | Wedelolactone | PKA pathway/NLRP3 | Macrophage | Mice | (62) |
| NSA | NLRP3/Caspase-1/GSDMD | Macrophage | Mice | (63) | |
| PEI-Chol/siGSDMD | NLRP3/Caspase-1/GSDMD | Macrophage | Mice | (64) | |
| Resveratrol | (Pink1/Parkin pathway)/NLRP3 | Macrophage | Mice | (65) | |
| Leojaponin | RAPTOR/NLRP3 | Macrophage | Mouse | (66) | |
| HQL6 | P2Y14R/cAMP/NLRP3 | / | Rat | (67) | |
| Gallic Acid | Nrf/ROS/NLRP3 | Macrophage | Mice | (50) | |
| 3-amide-5-aryl benzoic acid | P2Y14R/NLRP3 | Macrophage | Mice | (68) | |
| Corilagin | ROS/TXNIP/NLRP3 | Macrophage | Mice | (40) | |
| BF-2 | MAPK/NF-κB/NLRP3 | Macrophage | Mice | (69) | |
| NSC697923 | NLRP3/Caspase-1 | Macrophage | Mice | (45) | |
| Brd4 | NF-κB/NLRP3/GSDMD | Macrophage | Rat | (48) |
ICA, Icariin; HQH, Huai Qi Huang; BHGZD, Baihu-Guizhi decoction; MDP, monomeric derivatives of paeoniflorin; JWJG capsule, Jinwujiangu capsule; NSA, necrosulfonamide; PEI-Chol/siGSDMD, siGSDMD-loaded PEI-Chol lipopolymers; BF-2, Baeckein E.