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. 2023 Oct 10;169(10):001397. doi: 10.1099/mic.0.001397

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© 2023 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.

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Fig. 9. — Model to show the relationship between NagC, QS and GlcNAc metabolism in Y. pseudotuberculosis . NagC positively and negatively regulates the expression of the nag operon in a GlcNAc dependent manner. There is a reciprocal activator/repressor regulatory relationship between QS and NagC and NagC positively regulates biofilm formation, either directly or through the positive activation of hmsHFRS expression. The dashed lines represent our previous work defining the interdependent regulatory relationships between QS, biofilm, type three secretion, motility and histidine metabolism [20, 21, 32].