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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Alzheimers Dement. 2023 Feb 24;19(8):3537–3554. doi: 10.1002/alz.12970

Figure 1. CSF in aging and AD.

Figure 1.

(A) Characteristics of the CSF protein database from the Emory Goizueta ADRC cohort.

(B) The most significant Ingenuity pathways based on the CSF proteins changed by aging (p≤0.05).

(C) The most significant Ingenuity pathways based on the CSF proteins changed by aging in healthy individuals versus AD (p≤0.05).

(D) Volcano plot showing significantly changed CSF proteins in AD compared with healthy individuals in 45–55 (n=29), 56–65 (n=97), 66–75 (n=133) and 76–90 (n=38) year-old age groups (p≤0.05, NS: not significant).

(E) The most significant Ingenuity pathways based on the CSF proteins changed by aging in AD compared with healthy individuals in different age groups (p≤0.05).

(F) Sankey diagram showing significantly changed inflammatory pathways in AD compared with healthy individuals across different age groups (p≤0.05).